di 2 ethylhexyl phthalate cancer

  • Di 2 ethylhexyl phthalate OEHHA

    AI BEHP Bis 2 ehtylhexyl phthalate Di 2 ethylhexyl phthalate Diethylhexyl phthalate DEHP Ethylhexyl phthalate NCI C52733 Octyl phthalate Vinicizer 80 EPA Pesticide Chemical Code 295200. Occurrence/Use. Plasticizer for many resins and elastomers component of tobacco smoke

  • Di 2 ethylhexyl Phthalate Property Information

    Di 2 ethylhexyl Phthalate CAS No. Reasonably anticipated to be a human carcinogen First listed in the Third Annual Report on Carcinogens 1983 Also known as DEHP diethylhexyl phthalate or dioctyl phthalate C O O C H2C CH H2 C O O C H2 CH H2C C H2 H2 C CH3 C H2 CH3 CH3 C H2 H2 C CH3 H2 C Carcinogenicity Di 2 ethylhexyl phthalate

  • Bis 2 ethylhexyl phthalateWikipedia

    Bis 2 ethylhexyl phthalate di 2 ethylhexyl phthalate diethylhexyl phthalate DEHP dioctyl phthalate DOP is an organic compound with the formula C 6 H 4 CO 2 C 8 H 17 2 HP is the most common member of the class of phthalates which are used as plasticizers is the diester of phthalic acid and the branched chain 2 ethylhexanol.This colorless viscous liquid is soluble in oil but not

  • Di 2 ethylhexyl phthalate promotes lung cancer cell line

    Di 2 ethylhexyl phthalate DEHP is widely used in polyvinylchloride based materials and remains intact in the environment. Lungs are one route of entry of DEHP into the body however there is limited information on the effects and mechanism of action of DEHP on non small cell lung cancer NSCLC . Here we addressed this by examining the effect of DEHP on the proliferation of A549 human lung

  • The Impact of Di 2 ethylhexyl phthalate on Cancer Progression

    Di 2 ethylhexyl phthalate DEHP a widely used plasticizer mainly serves as an additive to render polyvinyl chloride PVC soft and flexible. PVC plastics have become ubiquitous in our modern society. Yet the leaching of DEHP from PVC based consumables ultimately results in the deposition in cert

  • PUBLIC HEALTH STATEMENT Di 2 ethylhexyl phthalate DEHP

    DEHP which is an abbreviation for di 2 ethylhexyl phthalate is a manufactured chemical that is commonly added to plastics to make them flexible. Other names for this compound are dioctyl phthalate DOP and bis 2 ethylhexyl phthalate BEHP . Note that di n octyl phthalate however is the name for a different chemical. Trade names

  • Di 2 Ethylhexyl Phthalate DEHP Public Health Statement

    DEHP which is an abbreviation for di 2 ethylhexyl phthalate is a manufactured chemical that is commonly added to plastics to make them flexible. Other names for this compound are dioctyl phthalate DOP and bis 2 ethylhexyl phthalate BEHP . Note that di n octyl phthalate however is the name for a different chemical.

  • Toxicological Summary for Di 2 ethylhexyl phthalate

    Di 2 ethylhexyl phthalate1 of 13 Toxicological Summary for Di 2 ethylhexyl phthalate CAS Health Based Guidance for Water Health Risk Assessment Unit Environmental Health Division . Adopted as Rule November 2015 . Synonyms DEHP Bis 2 ethylhexyl phthalate . Acute Non Cancer Health Risk Limit nHRL. Acute = 20 µg/L

  • Lifetime cancer risk assessment for inhalation exposure to

    The plasticizer di 2 ethylhexyl phthalate DEHP is ubiquitous in the environment and considered as carcinogen however the carcinogenic risk of human exposure to DEHP in the air via inhalation is lacking. A probabilistic incremental lifetime cancer risk ILCR model was implemented to quantitativ

  • Bis 2 ethylhexyl phthalate C24H38O4PubChem

    Bis 2 ethylhexyl phthalate is a phthalate ester that is the bis 2 ethylhexyl ester of benzene 1 2 dicarboxylic acid. It has a role as an apoptosis inhibitor an androstane receptor agonist and a plasticiser. It is a phthalate ester and a diester.

  • Di 2 ethylhexyl phthalate DEHP

    Di 2 ethylhexyl phthalate DEHP by Tamie Nakajima PhD Nancy B. Hopf PhD and Paul A. Schulte PhD Citation for most recent IARC review IARC Monographs Vol 77 2000. The use of di 2 ethylhexyl phthalate DEHP has been modified since the last Monograph. An estimated 90 of DEHP is used as a plasticizer for PVC Toxics Use Reduction Institute

  • NO SIGNIFICANT RISK LEVEL NSRL FOR THE PROPOSITION

    This document provides a basis for the estimation of cancer risk from exposure to di 2 ethylhexyl phthalate DEHP 1 . Epidemiological evidence is uninformative with respect to quantitative estimates of cancer risk to humans from exposure to DEHP. There is evidence that DEHP induces liver tumors in rats and mice by a mode of action common to a

  • Bis 2 ethylhexyl phthalate DEHP

    Bis 2 ethylhexyl phthalate is also called di 2 ethylhexyl phthalate or DEHP . 1 DEHP is a colorless liquid with almost no odor. 1 The chemical formula for DEHP is C 24 H 38 O 4 and the molecular weight is 390.57 g/mol. 1 The vapor pressure for DEHP is 6.2 10 8 mm Hg at 25 C and it has a log octanol/water partition coefficient log K ow

  • Up regulation of IL 6 is involved in di 2 ethylhexyl

    Di 2 ethylhexyl phthalate DEHP which is widely used in polyvinyl chloride materials can be easily accumulated into human body. Lung cancer cells can be directly exposed to DEHP via inhalation however the effects and related mechanisms of DEHP on the progression of non small cell lung cancer NSCLC were not illustrated.

  • The Impact of Di 2 ethylhexyl phthalate on Cancer

    Dec 05 2017  Di 2 ethylhexyl phthalate DEHP a widely used plasticizer mainly serves as an additive to render polyvinyl chloride PVC soft and flexible. PVC plastics have become ubiquitous in our modern society. Yet the leaching of DEHP from PVC based consumables ultimately results in the deposition in certain tissues via inadvertent applications.

  • Lifetime cancer risk assessment for inhalation exposure to

    Oct 07 2016  The plasticizer di 2 ethylhexyl phthalate DEHP is ubiquitous in the environment and considered as carcinogen however the carcinogenic risk of human exposure to DEHP in the air via inhalation is lacking. A probabilistic incremental lifetime cancer risk ILCR model was implemented to quantitatively estimate the potential cancer risk of DEHP via human inhalation by using Monte Carlo

  • Di 2 ethylhexyl phthalate promotes lung cancer cell line

    Di 2 ethylhexyl phthalate DEHP is widely used in polyvinylchloride based materials and remains intact in the environment. Lungs are one route of entry of DEHP into the body however there is limited information on the effects and mechanism of action of DEHP on non small cell lung cancer NSCLC .

  • Di 2 ethylhexyl phthalate DEHP Proposition 65 Warnings

    International Agency for Research on Cancer IARC IARC Monographs on the Evaluation of Carcinogenic Risks to Humans vol. 101 2013 . Di 2 ethylhexyl phthalate in Some Chemicals Present in Industrial and Consumer Products Food and Drinking water pages .

  • Di 2 ethylhexyl phthalate exposure exacerbates metabolic

    Jul 24 2021  In di 2 ethylhexyl phthalate DEHP treated mice transcriptional changes in white adipose tissue WAT were associated with adipocyte differentiation lipid

  • Di 2 ethylhexyl phthalate OEHHA

    Air Toxics Hot Spots Program Technical Support Document for Cancer Potencies. Appendix B. Chemical specific summaries of the information used to derive unit risk and cancer potency values. Updated 2011. OEHHA 1997. Public Health Goal for Di 2 ethylhexyl phthalate

  • Di 2 ethylhexyl phthalate DEHP increases proliferation

    The di 2 ethylhexyl phthalate DEHP is a plasticizer incorporated to plastic matrices of widely used consumer products. However it is gradually released from these products resulting in a chronic exposure for humans. Although DEHP similar to other members of the phthalates family is generally

  • Di 2 Ethylhexyl Phthalate IARC Summary Evaluation

    Di 2 ethylhexyl phthalate was tested in mice and rats by oral administration It significantly increased the incidence of benign and malignant liver cell tumours in animals of both species and a dose response relationship was observed. Di 2 ethylhexyl phthalate can cause testicular damage in rats. There is evidence that this compound and

  • PDF Tumor initiating and promoting activities of di 2

    Tumor initiating and promoting activities of di 2 ethylhexyl phthalate in vivo and in vitro. Download. Related Papers. Reversibility and Persistence of Di 2 ethylhexyl Phthalate DEHP and Phenobarbital Induced Hepatocellular Changes in Rodents. By James Klaunig.

  • A Cancer Risk Assessment of Di 2 ethylhexyl phthalate

    Jun 01 1999  Significant increase of 8 hydroxydeoxyguanosine in liver DNA of rats following short term exposure to the peroxisome proliferators di 2 ethylhexyl phthalate and di 2 ethylhexyl adipate Jpn. J. Cancer Res. Gann 81 1990 pp. 213215

  • PhthalatesProposition 65 Warnings Website

    DEHP di 2 ethylhexyl phthalate may increase the risk of cancer and may harm the male reproductive system. Also exposure to DEHP during pregnancy may affect the development of the child. DIDP di isodecyl phthalate during pregnancy may affect the development of the child. DINP diisononyl phthalate may increase the risk of cancer.

  • Di 2 ethylhexyl phthalate DEHP Proposition 65 Warnings

    Effects on Male Reproductive System 10/24/2003. Basis for Listing AB NIOSH /FDA. AI BEHP Bis 2 ehtylhexyl phthalate Di 2 ethylhexyl phthalate Diethylhexyl phthalate DEHP Ethylhexyl phthalate NCI C52733 Octyl phthalate Vinicizer 80 EPA Pesticide Chemical Code 295200.

  • Peroxisome proliferation due to di 2 ethylhexyl phthalate

    CARPENTER CP WEIL CS SMYTH HF. Jr Chronic oral toxicity of di 2 ethylhexyl phthalate of rats guinea pigs and dogs. AMA Arch Ind Hyg Occup Med. 1953 Sep 8 3 219–226. Google Scholar Lake BG Gangolli SD Grasso P Lloyd AG. Studies on the hepatic effects of orally administered di 2 ethylhexyl phthalate in the rat.

  • The Impact of Di 2 ethylhexyl phthalate on Cancer Progression

    Di 2 ethylhexyl phthalate DEHP a widely used plasticizer mainly serves as an additive to render polyvinyl chloride PVC soft and flexible. PVC plastics have become ubiquitous in our modern society. Yet the leaching of DEHP from PVC based consumables ultimately results in the deposition in cert

  • The Impact of Di 2 ethylhexyl phthalate on Cancer

    Dec 05 2017  Di 2 ethylhexyl phthalate DEHP a widely used plasticizer mainly serves as an additive to render polyvinyl chloride PVC soft and flexible. PVC plastics have become ubiquitous in our modern society. Yet the leaching of DEHP from PVC based consumables ultimately results in the deposition in certain tissues via inadvertent applications. Health risks for human populations exposed

  • Effect of di 2 ethylhexyl phthalate on Nrf2 regulated

    Jun 04 2020  Introduction. Exposure to persistent environmental pollutants such as phthalate has been linked to the induction of multiple human pathologies including diabetes and cancer Sun et al. 2015 .Once utilized extensively as plasticizers to impart flexibility transparency and durability of plastic materials the production of phthalate including di 2 ethylhexyl phthalate DEHP was banned in

  • Di 2 ethylhexyl phthalate DEHP increases proliferation

    The di 2 ethylhexyl phthalate DEHP is a plasticizer incorporated to plastic matrices of widely used consumer products. However it is gradually released from these products resulting in a chronic exposure for humans. Although DEHP similar to other members of the phthalates family is generally considered as an endocrine disruptor the

  • Di 2 ethylhexyl phthalate induced toxicity and peroxisome

    Jul 06 2019  The plasticizer di 2 ethylhexyl phthalate DEHP has been widely used in the manufacture of polyvinyl chloride containing products such as medical and consumer goods. Humans can easily be exposed to it because DEHP is ubiquitous in the environment. Recent research on the adverse effects of DEHP has focused on reproductive and developmental toxicity in rodents and/or

  • Di 2 ethylhexyl phthalate DEHP

    7/1/2020 Di 2 ethylhexyl phthalate DEHP DEHP is on the Proposition 65 list because it can cause cancer and birth defects or other reproductive harm. Exposure to DEHP may increase the risk of cancer and may also harm the male reproductive system.

  • Di 2 ethylhexyl phthalateSome Industrial Chemicals

    The degree of exposure to di 2 ethylhexyl phthalate was assessed in 11 patients undergoing haemodialysis for treatment of renal failure and showed that on average an estimated 105 mg di 2 ethylhexyl phthalate was extracted from the dialyser during a single 4 h dialysis session with a range of 23.8–360 mg. Time averaged circulating

  • Di 2 ethylhexyl phthalate DEHP CASRN IRISUS

    Jan 31 1987  Orally administered DEHP produced significant dose related increases in liver tumor responses in rats and mice of both sexes. This may be a synopsis of the full weight of evidence narrative. Quantitative Estimate of Carcinogenic Risk from Oral Exposure PDF 14 pp 121 K Oral Slope Factor 1.4 x 10 2 per mg/kg day.

  • Proposition 65listed chemicals

    Di 2 ethylhexyl phthalate DEHP Why am I being warned about potential exposure to DEHP DEHP is on the Proposition 65 list because it can cause cancer and birth defects or other reproductive harm. Exposure to DEHP may increase the risk of cancer and may also harm the male reproductive system.